近年来的基础及临床研究表明肿瘤形成、生长、浸润及转移的关键是肿瘤血管化。肿瘤生长需要血液提供氧气和营养 ,没有新血管生成 ,肿瘤维持微小状态不会对人体产生生命危险〔1〕。体内的新血管生成是由许多刺激因子和抑制因子控制的 ,它们与内皮细胞受体结合起调控作用〔2 ,3〕 In recent years, basic and clinical studies have shown that the key to tumor formation, growth, invasion and metastasis is tumor vascularization. Tumor growth requires blood to provide oxygen and nutrients, there is no new blood vessels, tumors maintain a small state does not have a life-threatening human [1]. In vivo neovascularization is controlled by a number of stimulatory and inhibitory factors that regulate the binding of endothelial cells to receptors [2,3]