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[Objective]To study the effects of flavonoids from Scutellaria stem and leaf (SSF) on the expression of NMDAR (N-methyl-D-as-partate receptor) and vascular endothelial growth factor (VEGF) in chronic cerebral ischemia rats.[Method]The model of chronic cerebral ischemia was established by bilateral carotid artery occlusion for 2 months with female SD rats.The effects of SSF were evaluated on mRNA expression in NMDAR of hippocampal cells and VEGF in cerebral cortex cells by the method of reverse transcription-polymerase chain reaction (RT-PCR).[Result]Compared with the sham group,the expression of NMDAR1,NMDAR2A and NMDAR2B in hippocampus and VEGF in cerebral cortex were significantly increased (P<0.01).However,The cerebral ischemia rats daily and orally administered SSF (17.5,35.0 and 70.0mg/kg) for 38 days appeared obviously reduced mRNA expressions of NMDAR1,NMDAR2A and NMDAR2B in hippocampus (P<0.05),and increased mRNA content of VEGF in the cortex (P<0.05).[Conclusion]SSF can decrease the expression of NMDAR in hippocampus,increase the expression of VEGF in cerebral cortex of cerebral ischemia rats,which suggested that the neuronal protection of SSF may be preformed by influencing the production of NMDAR and VEGF.