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目的了解焦炉工血清中肺癌标记物CA50、ACTH水平及其在肺癌早期诊断中的意义,为相关职业防护提供依据。方法以观察组200例、对照组79例为研究对象,采用放射免疫法检测其血清中CA50、ACTH水平。结果血清中CA50水平观察组明显高于对照组(P<0.01),并且有随着接触工龄的增长而升高的趋势;血清中ACTH的水平未见明显改变。结论血清标记物CA50对高危职业人群发生肺癌的危险性分析具有一定的意义。
Objective To understand the significance of lung cancer markers CA50 and ACTH in coke oven workers and their significance in the early diagnosis of lung cancer and provide evidences for occupational protection. Methods 200 cases in the observation group and 79 cases in the control group were studied. The serum levels of CA50 and ACTH were detected by radioimmunoassay. Results The level of CA50 in serum in the observation group was significantly higher than that in the control group (P <0.01), and there was a trend of increasing with the increase of working age. The level of serum ACTH had no obvious change. Conclusion Serum marker CA50 is of great significance to the risk analysis of lung cancer in high-risk occupational groups.