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胎膜早破是围产期病率和死亡率的重要原因之一,而临床上经常不能明确诊断。传统的诊断方法假阳性和假阴性率均高,且易有主观因素,并需要复杂的训练或准备,或有损伤性。在羊水中甲胎蛋白(AFP)含量很高,而尿或阴道分泌液中则无,故是特异性较准确的试验。随妊娠进展,AFP水平渐降低,所以足月前比足月时水平高。作者提出用单克隆抗体比色法测定AFP,可区别其它液体和羊水,是诊断未足月破膜的新方法。受试者为48例≤孕36周已确诊破膜的病人,平均孕周29.2±6周,17例孕周≤27周。全部病人均作羊齿样变和硝嗪试验以及快速AFP单克隆抗体比色试验。AFP单克隆抗体试验操作是:于后穹
Premature rupture of membranes is one of the important causes of perinatal morbidity and mortality, and often can not be diagnosed clinically. Traditional diagnostic methods are false-positive and false-negative rates are high, and prone to subjective factors, and require complex training or preparation, or traumatic. AFP in amniotic fluid content is high, but no urine or vaginal secretions, it is more specific and specific test. With the progress of pregnancy, AFP levels gradually decreased, so before full-term level than the full-time high. The authors propose monoclonal antibody colorimetric determination of AFP, distinguishable from other liquids and amniotic fluid, is a new method for the diagnosis of inadequate rupture of membranes. The subjects were 48 cases of patients with proven rupture of membranes at 36 weeks of gestation, with an average gestational age of 29.2 ± 6 weeks and 17 gestational weeks ≤27 weeks. All patients were made mutton-like and nitrazine test and fast AFP monoclonal antibody colorimetric assay. AFP monoclonal antibody test operation is: in the posterior dome