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为了进一步探讨先天性尿道下裂患儿的内分泌异常 ,作者应用冰冻切片直接荧光组织化学法对 2 3例患儿阴茎组织中的雄激素受体 (AR) ,雌激素受体 (ER)和孕激素受体 (PR)进行了检测。结果发现 :(1)尿道下裂和正常阴茎组织中均有这三种受体的表达 ,而且它们在尿道下裂和正常阴茎组织中的含量和分布情况相似 ,都是AR含量最高 ,ER最低 (P <0 .0 5 )。 (2 )尿道下裂阴茎组织中AR量与对照 (10例包皮环切 )相比无显著的统计学差异(P >0 .0 5 ) ,ER和PR则比对照明显增加 (P <0 .0 5 )。 (3)三种受体在不同临床类型尿道下裂阴茎组织中的含量和分布无显著差异 (P >0 .0 5 )。 (4)受体阳性细胞主要分布在皮肤浅层。以上结果表明先天性尿道下裂可能不单涉及到某一种激素受体的缺陷 ,而可能与整个生殖内分泌系统的异常有关。
In order to further explore the endocrine abnormalities in children with congenital hypospadias, the authors applied frozen sections direct fluorescence histochemical method in 23 cases of children with penile tissue androgen receptor (AR), estrogen receptor (ER) and pregnancy Hormone receptor (PR) was tested. The results showed that: (1) The expression of these three receptors was found in both hypospadias and normal penile tissues, and their content and distribution in hypospadias and normal penis tissues were similar, with the highest AR content and the lowest ER (P <0. 05). (2) The amount of AR in penile tissue of hypospadias was not significantly different from that in control (10 cases of circumcision) (P> 0.05), ER and PR were significantly increased (P <0. 0 5). (3) There was no significant difference in the content and distribution of the three receptors in the penile tissues of different types of hypospadias (P> 0.05). (4) Receptor positive cells are mainly located in the superficial layer of the skin. The above results suggest that congenital hypospadias may not only involve the defects of a hormone receptor, but may be related to the abnormalities of the entire reproductive and endocrine system.