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目的:探讨血清白蛋白(ALB)水平在经典型霍奇金淋巴瘤(CHL)患者预后中的意义。方法:收集2001年5月至2008年12月在中山大学肿瘤防治中心经病理确诊初治的96例经典型霍奇金淋巴瘤患者的临床资料进行回顾性分析。根据ALB水平比较患者的总生存率(OS)和无失败生存率(FFS)。结果:治疗前96例经典型霍奇金淋巴瘤患者中有17例ALB<35 g/L及79例ALB≥35 g/L。比较两组患者的基线临床特征,结果显示在年龄、性别、Ann Arbor分期、巨大肿块、结外侵犯、淋巴结区域、LDH水平比较均无统计学差异(P>0.05)。ALB<35 g/L和ALB≥35 g/L患者的5年FFS分别为60.1%和91.6%(P=0.022),但OS并无统计学意义(P=0.131)。多因素分析结果示仅ALB<35 g/L是FFS的独立预后不良因素(P=0.030),而OS的独立预后因素为年龄≥60岁(P=0.020)。结论:本研究结果显示治疗前ALB水平对判断CHL患者的预后有一定临床意义,其可能成为一项新的预后指标用于早晚期CHL患者。
Objective: To investigate the significance of serum albumin (ALB) in the prognosis of patients with classic Hodgkin’s lymphoma (CHL). Methods: A retrospective analysis was performed on the clinical data of 96 patients with classic Hodgkin ’s lymphoma who were diagnosed as pathologically diagnosed at Cancer Center of Sun Yat-sen University from May 2001 to December 2008. Patients were compared for overall survival (OS) and failure-free survival (FFS) based on ALB levels. Results: Of the 96 patients with classical Hodgkin’s lymphoma, 17 had ALB <35 g / L and 79 had ALB ≥ 35 g / L before treatment. Baseline clinical characteristics were compared between the two groups. The results showed no significant difference (P> 0.05) in age, gender, Ann Arbor stage, huge mass, extranodal invasion, lymph node area and LDH levels. The 5-year FFS for patients with ALB <35 g / L and ALB ≥ 35 g / L was 60.1% and 91.6%, respectively (P = 0.022), but OS was not statistically significant (P = 0.131). Multivariate analysis showed that only ALB <35 g / L was an independent prognostic factor for FFS (P = 0.030), whereas the independent prognostic factor for OS was ≥60 years (P = 0.020). CONCLUSION: The results of this study show that ALB level before treatment is of clinical significance in judging the prognosis of patients with CHL, which may be a new prognostic indicator for early and late CHL patients.