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目的 探讨短期胰岛素强化治疗对2型糖尿病(T2DM)患者胰岛B细胞功能的影响。方法 2003-11~2004-09在中国医科大学第一临床学院收治T2DM患者,应用化学免疫发光法测定强化治疗前后T2DM患者血清胰岛素和C肽水平。结果 强化治疗后的T2DM患者OGTT试验中0、30、60、120、180min血清胰岛素和C肽水平均较治疗前明显升高。结论 短期胰岛素强化治疗可使胰岛素分泌减低的T2DM患者胰岛B细胞得到休息,从而促其功能部分恢复。
Objective To investigate the effect of short-term intensive insulin therapy on islet B cell function in patients with type 2 diabetes mellitus (T2DM). METHODS: From November 2003 to September 2004, T2DM patients were admitted to the First Clinical College of China Medical University. The levels of serum insulin and C-peptide in T2DM patients before and after intensive treatment were measured by chemiluminescence immunoassay. Results Serum levels of insulin and C-peptide at 0, 30, 60, 120 and 180 minutes after intensive treatment in T2DM patients were significantly higher than those before treatment. Conclusion Short-term intensive insulin therapy can reduce the insulin secretion in T2DM patients with islet B cells to rest, thus contributing to its functional recovery.