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目的报道1例成人肾母细胞瘤,结合文献探讨其临床及病理组织学特点。方法对1例成人肾母细胞瘤进行常规病理、免疫组化分析。结果成年男性患者,临床表现乏力、纳差2个月,体检发现左肾占位1周。镜下可见肿瘤主要有三种成分组成,即未分化胚芽组织、间胚叶性间质和上皮成分。免疫组化瘤细胞表达Vimentin(■)、SM-actin(■)、CK(■)、CK18(+)、EMA(+)、CD34(+),不表达CEA(-)。结论发生于成人的肾母细胞瘤极为少见,其组织学特点和治疗原则与儿童肾母细胞瘤相同。
Objective To report a case of adult Wilms’ tumor of the kidney and to investigate its clinical and histopathological features in combination with the literature. Methods One case of adult Wilms’ tumor was subjected to routine pathological and immunohistochemical analysis. Results Adult male patients, clinical manifestations of fatigue, anorexia for 2 months, physical examination found that the left kidney occupies 1 week. Microscopically visible tumors are mainly composed of three components, namely undifferentiated germ tissue, interstitial mesenchyme and epithelial components. Immunohistochemically expressed Vimentin (-), SM-actin (-), CK (-), CK18 (+), EMA (+), CD34 (+), but not CEA (-). Conclusion The occurrence of nephroblastoma in adults is extremely rare. The histological features and treatment principles are the same as those in children with nephroblastoma.