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研究早产与母亲绒毛膜羊膜炎和新生儿脐血白细胞介素-6(IL-6)水平三者间的相互关系,探讨早产发生的可能机制。方法 用ELISA方法检测新生儿脐血IL-6水平,胎膜组织行病理检查。结果 母亲有绒毛膜羊膜炎组早产发生的频率以及新生儿脐血IL-6水平皆明显高于无绒毛膜羊膜炎组;早产儿中母亲有绒毛膜羊膜炎组脐血IL-6水平较早产不伴母亲感染组及足月组皆显著升高;以胎膜病理学检查结果为标准,脐血IL-6水平≥1.00ng/ml可以作为快速诊断亚临床绒毛膜羊膜炎的指标,其敏感度为90.0％,特异度为79.6％。结论 母亲的绒毛膜羊膜炎、IL-6水平升高与早产的发生密切相关,故预防和积极治疗母亲的宫内感染对预防早产的发生具有重要意义。脐血IL-6水平升高提示早产与母亲的感染有关。
To investigate the relationship between preterm birth and maternal chorioamnionitis and neonatal cord blood interleukin-6 (IL-6) levels and explore the possible mechanism of preterm birth. Methods The level of IL-6 in neonatal cord blood was detected by ELISA and the fetal tissue was examined by pathology. Results The frequency of maternal chorioamnionitis preterm birth and neonatal cord blood IL-6 levels were significantly higher than those without chorioamnionitis; preterm children with chorioamnionitis group of umbilical cord blood IL-6 levels were premature The level of IL-6 in cord blood≥1.00ng / ml could be used as an index for rapid diagnosis of subclinical chorioamnionitis, which was sensitive to Degree was 90.0%, specificity was 79.6%. Conclusion Maternal chorioamnionitis and elevated levels of IL-6 are closely related to the occurrence of prematurity. Therefore, prevention and active treatment of intrauterine infection of the mother is of great significance in preventing the occurrence of preterm birth. Elevated levels of IL-6 in cord blood suggest that preterm labor is associated with mother’s infection.