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作者对10名接受庆大霉素或卡那霉素的婴儿肉毒中毒病人的回顾性研究指出氨基甙类抗菌素能加重这些病人的肌软弱和促使呼吸衰竭。从婴儿肉毒中毒病程中区别氨基甙类抗菌素这一作用是困难,但给予氨基甙类抗菌素后迅速出现病情恶化(如:自发活动丧失,张口反射受损、呼吸障碍),而停药后迅速恢复是诊断的有力依据。在实验模型中氨基甙类抗菌素可引起神经肌肉冲动传递阻滞,並可加剧重症肌无力病人和箭毒引起的肌软弱。但氨基甙类抗菌素和肉毒毒素的
A retrospective study of 10 patients with botulism of infants who received gentamicin or kanamycin pointed out that aminoglycoside antibiotics can aggravate muscular weakness and promote respiratory failure in these patients. It is difficult to distinguish aminoglycoside antibiotics from the course of botulinum toxin infantile disease, but aggravating conditions (such as loss of spontaneous activity, impaired mouth reflex, and respiratory disorders) immediately after administration of aminoglycoside antibiotics are rapid Recovery is a strong basis for diagnosis. Aminoglycoside antibiotics cause neuromuscular blockade in the experimental model and aggravate muscular weakness caused by myasthenia gravis and arrow poison. But aminoglycoside antibiotics and botulinum toxin