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目的 :研究单纯注射胶体32 P和先注入聚合白蛋白 (MAA) ,再注射胶体32 P两种不同给药方法的32 P体内分布情况 ,探讨MAA减少肝癌组织内的32 P胶体血行扩散的作用。方法 :在Balb/c小鼠右侧胸前皮下接种H2 2 肝癌细胞 ,10天后长出直径约 1cm的肿瘤。将其随机分为 2组 :第 1组只注射胶体32 P 1.85MBq ;第 2组先注入 1× 10 5颗粒MAA ,再注入胶体32 P 1.85MBq。注射后 30分钟、2 4小时、48小时、8天和 16天分别测定肿瘤组织、外周血液和心、肝、脾、肾、骨髓的放射性。结果 :预先注射MAA组 ,32 P在肿瘤组织内的滞留量大 ,而在血液中和各脏器的放射性低。结论 :MAA可能有效阻止32 P的全身扩散 ,使胶体32 P长时间滞留在肿瘤内
OBJECTIVE: To study the in vivo distribution of 32 P injected by colloidal 32 P and injecting polyaluminum albumin (MAA) before injection of colloidal 32 P, and to investigate the effect of MAA in reducing the diffusion of 32 P colloid in hepatocellular carcinoma. . Methods: H2 2 liver cancer cells were inoculated subcutaneously on the right chest of Balb/c mice. After 10 days, tumors with a diameter of about 1 cm were grown. They were randomly divided into two groups: the first group was injected with colloidal 32 P 1.85 MBq; the second group was injected with 1×10 5 particles of MAA first, and then injected with colloidal 32 P 1.85 MBq. At 30 minutes, 24 hours, 48 hours, 8 days, and 16 days after injection, radioactivity in tumor tissues, peripheral blood, and heart, liver, spleen, kidney, and bone marrow was measured. RESULTS: Pre-injection of MAA group had a large retention of 32 P in the tumor tissue and low radioactivity in the blood and organs. Conclusion : MAA may effectively prevent the systemic diffusion of 32 P, leaving colloidal 32 P to remain in the tumor for a long time