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目的了解皮肤基底细胞癌和皮肤鳞状细胞癌组织中Livin和Caspase-3的表达情况及二者的关系。方法采用免疫组化法检测25例基底细胞癌、18例鳞状细胞癌组织中Livin和Caspase-3的表达情况。结果①Livin蛋白在正常皮肤组织中不表达,基底细胞癌和鳞状细胞癌组织中Livin蛋白的阳性表达率分别为64.00%和72.22%。②Caspase-3在正常皮肤组织中表达,且明显高于基底细胞癌和鳞状细胞癌组织中Caspase-3的表达。③Caspase-3的表达与Livin的表达呈显著负相关。结论Livin在基底细胞癌和鳞状细胞癌组织中高表达,Caspase-3蛋白在基底细胞癌和鳞状细胞癌组织中低表达,且与Livn的表达呈负相关,提示二者可能共同参与基底细胞癌和鳞状细胞癌发病过程。
Objective To investigate the expression of Livin and Caspase-3 in basal cell carcinoma of the skin and squamous cell carcinoma of the skin and their relationship. Methods Immunohistochemistry was used to detect the expression of Livin and Caspase-3 in 25 cases of basal cell carcinoma and 18 cases of squamous cell carcinoma. Results 1 Livin protein was not expressed in normal skin tissues. The positive rates of Livin protein in basal cell carcinoma and squamous cell carcinoma tissue were 64.00% and 72.22%, respectively. 2 Caspase-3 was expressed in normal skin tissue and was significantly higher than that of basal cell carcinoma and squamous cell carcinoma. 3 The expression of Caspase-3 was significantly negatively correlated with the expression of Livin. Conclusions Livin is highly expressed in basal cell carcinoma and squamous cell carcinoma tissues. Caspase-3 protein is lowly expressed in basal cell carcinoma and squamous cell carcinoma tissues and negatively correlated with Livn expression, suggesting that they may be involved in basal cells. The pathogenesis of cancer and squamous cell carcinoma.