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目的探讨卵巢原发性类癌临床病理学特点及其鉴别诊断。方法收集张掖市人民医院1999年至2009年3例卵巢原发性类癌患者的临床资料、病理学检查及免疫表型结果 ,结合文献复习进行分析。结果巨检肿物均有完整包膜,2例为实性,1例为囊实性,镜检细胞多有不同排列方式,容易与其他类型的肿瘤混淆。在免疫组化染色中,常表达CD56、突触素(Syn)、神经元特异性烯醇化酶(NSE)、嗜铬蛋白(CgA),细胞角蛋白(CK)常呈不稳定性表达。结论卵巢原发性类癌发病率极低,临床上常无症状,其恶性程度低,预后好。影像学检查有助于发现卵巢的占位性病变,确诊需要病理学诊断,免疫组化有助于诊断。
Objective To investigate the clinicopathological features and differential diagnosis of primary carcinoid ovary. Methods The clinical data, pathological examination and immunophenotypic results of 3 cases of ovarian primary carcinoid patients from 1999 to 2009 in Zhangye Municipal People’s Hospital were collected and analyzed with literature review. Results The macroscopic masses had a complete capsule, 2 were solid, 1 was cystic solid, microscopic examination of cells arranged in different ways, easily confused with other types of tumors. In immunohistochemical staining, CD56, Syn, NSE, CgA and CK were often expressed in an unstable manner. Conclusions The incidence of primary carcinoid ovarian cancer is very low, clinically asymptomatic, its malignancy is low, the prognosis is good. Imaging studies can help identify ovarian lesions, diagnosis requires pathological diagnosis, immunohistochemistry contribute to the diagnosis.