雷公藤Triptergium wilfordii HooR.f,系卫矛科雷公藤属植物。有剧毒。本试验系采用湖南岳阳地区产的雷公藤根,经乙醇提取而制成片剂。成人用量每次600mg(相当原生药4g)。 1.毒性试验:取三组小鼠,每组3只,分别按成人剂量(1.2g/kg)的100,300,500倍灌胃给药。给药时间为下午4点。结果第一组小鼠用药后拒食、喜卧不活动。66小时恢复正常饮食及活动。第二组小鼠 Triptergium wilfordii HooR.f, which belongs to the genus Euonymus. Poisonous. In this experiment, Tripterygium wilfordii produced in the Yueyang area of ​​Hunan Province was used to produce tablets by ethanol extraction. Adult use 600mg each time (compared with 4g of the original drug). 1. Toxicity test: Take 3 groups of mice, 3 in each group, and gavage at 100, 300, 500 times adult dose (1.2g/kg) respectively. The dosing time is 4 PM. Results The first group of mice refused to eat after treatment and were inactive. 66 hours normal diet and activities resumed. The second group of mice