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为了确立钙通道阻滞剂(CCB)在防治肝硬化食管静脉曲张破裂出血的地位,本文通过Magnus法实验(离体门静脉收缩效应),经纤维胃镜直接测定曲张静脉压力(EVP)、脉冲多普勒超声检查、经皮肝穿刺门静脉造影术(PTP)及临床随访五个途径,在494只大鼠及321例患者中,对硝苯吡啶(Nif)、异搏停(Ver),脑益嗪(Cin)、汉防已甲素(Tet)以及心得安(Prop)进行了对照研究。一、各种CCB均能使钾离子和去甲肾上腺所引起门静脉收缩的剂量-效应曲线呈非平行右移,并降低最大反应值.Nif的PD_(?)值分别为7.1204和6.3462,Ver为6.1754和7.1049,Tet为5.4980和5.5121以及Cin为5.3406和3.8732.说明Nif和Ver对高体大鼠门静脉的作用较Tet和Cin更为强烈。
In order to establish the role of calcium channel blocker (CCB) in the prevention and treatment of hepatic cirrhosis with esophageal variceal bleeding, this study was to determine the variceal pressure (EVP), pulse doppler (Nif), verapamil (15 mg / kg), etoposide (15 mg / kg), cetuximab Cin, Tet and Prop. A variety of CCB can potassium ion and norepinephrine caused by contraction of the portal vein contraction-dose-response curve showed a non-parallel shift, and reduce the maximum response value.Nif’s PD_ (?) Values were 7.1204 and 6.3462, Ver 6.1754 and 7.1049, Tet for 5.4980 and 5.5121, and Cin for 5.3406 and 3.8732, indicating that Nif and Ver are more potent than Tet and Cin in the portal vein of high body rats.