论文部分内容阅读
目的探讨2型糖尿病肾病不同时期肾脏血流动力学改变及彩色多普勒超声的应用价值。方法将79例2型糖尿病患者根据尿微量白蛋白排泄率(UAER)和血肌酐水平(SCr)分为4组:A1组(UAER<20μg/min,SCr≤109.6μmol/L),A2组(UAER20-200μg/min,SCr≤109.6μmol/L),A3组(UAER>200μg/min,SCr≤109.6μmol/L),A4组(UAER≥0.5 g/24 h,SCr>109.6μmol/L),同时选择正常健康者30例作为对照组,应用彩色多普勒超声测量肾动脉血流参数Vsys、Vm、Vdias、PI、RI和每分钟肾动脉血流量(Q),进行统计学分析。结果 2型糖尿病早期患者Vsys、Vm、Q增高,与对照组比较差异有统计学意义。随着肾损害的加重,肾动脉Vsys、Vm、Vdias、Q呈逐渐下降的趋势,RI呈逐渐升高的趋势。结论彩色多普勒测量肾动脉血流指标对判断糖尿病肾损害的严重程度有一定价值。
Objective To investigate the changes of renal hemodynamics and color Doppler echocardiography in patients with type 2 diabetic nephropathy at different stages. Methods 79 patients with type 2 diabetes mellitus were divided into 4 groups according to urinary albumin excretion rate (UAER) and serum creatinine (SCr): group A1 (UAER <20μg / min, SCr≤109.6μmol / L) (UAER> 200μg / min, SCr≤109.6μmol / L), A4 group (UAER≥0.5 g / 24 h, SCr> 109.6μmol / L) At the same time, 30 normal healthy subjects were selected as the control group, and the renal artery blood flow parameters Vsys, Vm, Vdias, PI, RI and renal artery blood flow per minute (Q) were measured by color Doppler ultrasound. Results Vsys, Vm and Q in early stage of type 2 diabetes increased significantly compared with the control group. With the aggravation of renal injury, Vsys, Vm, Vdias, Q of renal artery showed a gradual downward trend, RI showed a gradual upward trend. Conclusion Color Doppler measurement of renal artery blood flow index to determine the severity of diabetic nephropathy has some value.