目的探讨圣母乳宝口服液对大鼠的长期毒性。方法取大鼠60只 ,雌雄各半 ,随机均分为3组 ,高剂量组给药200ml/Kg/d、低剂量组给药20ml/Kg/d和空白组给水20ml/Kg/d ,均连续给药21天。作血液学、血液生化学检查 ,主要脏器作肉眼及组织学检查。将结果与空白组比较 ,作统计学处理。结果高剂量组引起大鼠的血清TP、GLU降低 ,未见引起其它明显毒性反应 ,停药两周后TP、GLU与空白组比较无显著差异。结论本品按临床拟用剂量、途径、疗程应用是安全的。 Objective To investigate the long-term toxicity of Shenglu Milk Capsule in rats. Methods Sixty male and female rats were randomly divided into 3 groups: 200ml / Kg / d in the high-dose group, 20ml / kg / d in the low-dose group and 20ml / kg / d in the blank group Continuous administration of 21 days. For hematology, blood biochemical tests, the main organs for macroscopic and histological examination. The results were compared with the blank group for statistical analysis. Results The serum TP and GLU of rats in high dose group were decreased, and no other obvious toxic reaction was found. There was no significant difference between TP and GLU two weeks after drug withdrawal in blank group. Conclusion This product is intended to be used clinically dose, route, treatment application is safe.