论文部分内容阅读
人类巨细胞病毒(HCMV)感染极为普遍,多数感染者无临床症状。表现为隐性感染。病毒长期潜伏体内,在大量输血、妊娠、肿瘤、器官移植等情况下,潜伏病毒被激活而引起多种疾病,如巨细胞病毒传染性单核细胞增多症、肝炎、心肌炎和Guillian—Barre 综合症。先天性感染HCMV 的婴儿,5～10%临床表现为智力低下,发育迟缓,先天畸形及巨细胞包涵体病。此外,在人纤维母细胞株能查出有HCMV 的整合基因,提示HMV 象其它疱疹病毒一样具有潜在的致癌性。因此,在临床实践及优生优育中,HCMV 感染具
Human cytomegalovirus (HCMV) infection is extremely common, most of the infected without clinical symptoms. Invisible infection. Long-term latent virus in vivo, in a large number of blood transfusions, pregnancy, cancer, organ transplantation, etc., the latent virus is activated and cause a variety of diseases, such as cytomegalovirus infectious mononucleosis, hepatitis, myocarditis and Guillian-Barre syndrome . Congenital HCMV infection in infants, 5 to 10% of clinical manifestations of mental retardation, stunting, congenital malformations and giant cell inclusion disease. In addition, the integration of HCMV-containing genes can be detected in human fibroblasts, suggesting that HMV is potentially carcinogenic like other herpesviruses. Therefore, in clinical practice and prenatal and postnatal care, HCMV infection