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目的 探讨乳腺导管浸润癌微血管密度 (MVD)与血管内皮细胞生长因子 (VEGF)表达的关系以及与其临床病理特点的相关性。方法 应用免疫组化S P法检测 5 2例乳腺癌组织中微血管密度及VEGF的表达 ,同时分析其与临床病理特点间的关系。结果 ①癌肿中央MVD为 (10 1 4± 30 8)个 /mm2 ,而癌旁组织MVD为 (146 3± 5 4 2 )个 /mm2 ,两组差异有显著性 (P <0 0 1) ;②有腋窝淋巴结转移组MVD为 (138 4± 5 2 1)个 /mm2 ,无腋窝淋巴结转移组MVD为 (97 8± 33 5 )个 /mm2 ,两组差异有显著性 (P <0 0 5 ) ;③转移组VEGF表达阳性率为 87 7% (2 8/ 32 ) ,无转移组为 5 5 % (11/ 2 0 ) ,两组差异有显著性 (P <0 0 1) ;④VEGF阳性组MVD为 132 5个 /mm2 ,而VEGF阴性组MVD为 91 2个 /mm2 ,MVD和VEGF的表达具有相关性(P <0 0 1)。结论 肿瘤细胞表达VEGF可能是微血管密度增加的主要因素 ,乳腺癌血管生成与腋窝淋巴结的转移关系密切。
Objective To investigate the relationship between the microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) in invasive ductal carcinoma of the breast and their clinicopathological features. Methods Immunohistochemical SP method was used to detect the microvessel density and the expression of VEGF in 52 cases of breast cancer, and to analyze its relationship with clinicopathological features. Results ① The central MVD of the tumor was (10 1 4 ± 30 8) / mm 2 and the MVD of the adjacent tissue was (146 3 ± 5 4 2) / mm 2, with significant difference between the two groups (P 0 01) ; ② The MVD in axillary lymph node metastasis group was (138 4 ± 5 2 1) / mm2, and the MVD in axillary lymph node metastasis group was (97 8 ± 33 5) / mm2, with significant difference between the two groups (P <0 0 5). The positive rate of VEGF expression in the metastasis group was 87.7% (28/32) in the metastasis group and 55% (11/20) in the metastasis group, with significant difference between the two groups (P <0.01) MVD was 132 5 / mm2 in the positive group, and 91 2 / mm2 in the VEGF-negative group. There was a correlation between MVD and VEGF expression (P <0.01). Conclusion The expression of VEGF in tumor cells may be the main factor for the increase of microvessel density. The angiogenesis of breast cancer is closely related to the metastasis of axillary lymph nodes.