心脏疾患、体内电解质的紊乱、开胸手术和某些药物均可引起心律失常。根据临床资料,急性心律失常占急性心肌梗塞死亡率的50％以上。所以应用药物防治心律失常仍具有重要意义。近年来,微电极技术应用于心肌电生理的研究有所发展,对心肌的生理特性、心律失常的发生和发展规律、以及抗心律失常药物的药理作用得到进一步认识。以下仅就较常用的抗心律失常药物作一概括介绍。心肌的生理特性与心律失常一、自动节律性:人、动物的在体和离体心脏,在适当的环境中,能自动有节律地 Heart disease, electrolyte imbalance in the body, thoracotomy and certain medications can cause arrhythmias. According to clinical data, acute arrhythmia accounts for more than 50% of acute myocardial infarction mortality. Therefore, the application of drugs to prevent arrhythmia is still important. In recent years, the application of microelectrode technology to the study of myocardial electrophysiology has been developed. The physiological characteristics of myocardium, the occurrence and development of arrhythmia, and the pharmacological effects of antiarrhythmic drugs are further recognized. The following is only a more general introduction of anti-arrhythmic drugs. Cardiac physiological characteristics and arrhythmia A, automatic rhythmicity: human and animal in vivo and isolated heart, in an appropriate environment, can automatically rhythmically