Problems related to fault detection of networked control systems (NCSs) with both uncertain time-varying delay and quantization error are studied in this paper. A novel model with the form of polytopic uncertainty is given to represent the influences of both the time-varying delay and the quantization error, and then the reference model based method is used to design the residual generator that is robust to both unknown network-induced delay and unknown inputs. A numerical example is also given to illustrate the merits of the presented method. The proposed method can be regarded as an extension of the authors’ former work, which can only deal with time-varying delay. Problems related to fault detection of networked control systems (NCSs) with both uncertain time-varying delay and quantization errors are studied in this paper. A novel model with the form of polytopic uncertainty is given to represent the influences of both the time-varying delay and the quantization error, and then the reference model based method is used to design the residual generator that is robust to both unknown network-induced delay and unknown inputs. The proposed method can be considered as an extension of the authors’ former work, which can only deal with time-varying delay.