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目的 :以高分辨CT(HRCT)的影象学结构改变为标准探讨肺功能检查与肺间质病变之间的关系 ,进一步评价肺功能在肺间质纤维化诊断中的意义。方法 :分析 2 0例肺间质纤维化的病人常规和脉冲振荡肺功能诸指标和HRCT下影象学结构早期肺泡炎和晚期的肺间质纤维化半定量的结果之间的关系。结果 :常规肺功能以肺泡炎病变为主的病人 ,用力肺活量 (FVC)较为敏感 ,而以间质纤维化为主的病变 ,肺—氧化碳弥散 (DLCO)仍不失为一种有用的指标。对间质性肺病的早期脉冲振荡肺功能并不敏感而只是在肺间质纤维化形成后期而响应频率并与肺间质纤维化的程度相关。结论 :常规肺功能指标FVC、DLCO及肺冲振荡肺功能指标响应频率对肺间质纤维化的诊断有一定的意义。
OBJECTIVE: To investigate the relationship between pulmonary function tests and pulmonary interstitial lesions by using the image structure of high resolution CT (HRCT) as the standard to further evaluate the significance of lung function in the diagnosis of pulmonary fibrosis. Methods: The relationship between routine and pulsatile pulmonary function in 20 patients with pulmonary fibrosis and the semi-quantitative results of early pulmonary alveolitis and advanced pulmonary fibrosis in the imaging structure under HRCT were analyzed. Results: Conventional lung function was mainly sensitive to forced vital capacity (FVC) in patients with alveolitis lesions. However, DLCO was still a useful indicator of interstitial fibrosis-predominant disease. Is not sensitive to early impulsive lung function in interstitial lung disease but only to the late stage of pulmonary interstitial fibrosis and responds to the frequency and correlates with the degree of interstitial fibrosis. Conclusion: The common pulmonary function indicators FVC, DLCO and lung red oscillation pulmonary function index response frequency of pulmonary interstitial fibrosis diagnosis has a certain significance.