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C-erbB_2又称neu基因，是1985年确认的V-erbB_2相关的原癌基因，编码一个185KD的糖蛋白，与表皮生长因子受体（EGFR）十分近似，通过基因扩增和蛋白产物的过度表达而与人类肿瘤发生有关。P185neu在乳腺癌、卵巢癌、前列腺癌、胃癌及肺癌等［1］肿瘤中均有不同程度的过度表达，?
C-erbB_2, also known as the neu gene, is a V-erbB2-associated proto-oncogene identified in 1985 and encodes a 185-kD glycoprotein that closely resembles the epidermal growth factor receptor (EGFR) through gene amplification and overproduction of protein products. Expression is related to human tumorigenesis. P185neu is overexpressed to varying degrees in breast, ovarian, prostate, gastric and lung cancers [1].