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目的探讨冠心病患者冠状动脉病变狭窄程度对心率变异性(HRV)的影响及其临床意义。方法:将经冠状动脉造影证实冠状动脉管腔狭窄≥50%～70%定为中度狭窄组46例,>70%以上定为重度狭窄组41例,正常对照组38例,术前行24h动态心电图,计算HRV时域指标。结果:中、重度狭窄组HRV指标中SDNN、SDANN均显著低于正常对照组(P<0.01),重度狭窄组HRV指标中SDNN、SDANN显著低于中度狭窄组(P<0.01)。结论:冠心病患者HRV的降低与冠脉病变狭窄程度有关,提示HRV可作为预测冠心病严重程度和预后的重要指标。
Objective To investigate the effect of coronary artery stenosis on heart rate variability (HRV) and its clinical significance in patients with coronary heart disease. Methods: Coronary artery stenosis≥50% ~ 70% confirmed by coronary angiography was defined as 46 cases of moderate stenosis group, 41 cases of severe stenosis group> 70%, 38 cases of normal control group, 24h Holter, calculated HRV time domain indicators. Results: The SDNN and SDANN of HRV indexes of moderate and severe stenosis group were significantly lower than those of normal control group (P <0.01). SDNN and SDANN of HRV index of severe stenosis group were significantly lower than those of moderate stenosis group (P <0.01). Conclusion: The reduction of HRV in patients with coronary heart disease is related to the degree of coronary artery stenosis. It suggests that HRV can be used as an important index to predict the severity and prognosis of coronary heart disease.