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目的:初步探明黄花油点草活血作用药效的物质基础。方法:采用小鼠耳廓微循环及大鼠出、凝血时间和血栓形成实验考察黄花油点草不同提取物的活血作用。结果:给药剂量为2.5 g/kg时,水提取物具有显著增加血瘀小鼠动、静脉管径及血流速度变化值,延长血瘀小鼠凝血时间及抗血瘀大鼠血栓形成作用,甲醇提取物具有显著增加血瘀小鼠动脉管径及动、静脉血流速度变化值和延长血瘀小鼠凝血时间的作用;70%乙醇提取物具有显著改善血瘀小鼠动、静脉血流速度作用。结论:黄花油点草活血作用主要药效部位为水提取物,其发挥作用的机制为改善微循环及抗血栓形成。
Objective: To initially ascertain the material basis of the medicinal effect of Huanghua oil on promoting blood circulation. Methods: The mouse auricle microcirculation and rat out, clotting time and thrombosis experiments Huanhuayuan different extracts of the role of blood circulation. Results: At the dosage of 2.5 g / kg, water extract significantly increased the arterial and venous caliber and blood flow velocity in blood stasis mice, prolonged the clotting time in blood stasis mice and thrombosis in anti-blood stasis rats , Methanol extract can significantly increase the arterial diameter and arterial and venous blood flow velocity changes in blood stasis mice and prolong the clotting time of blood stasis mice; 70% ethanol extract can significantly improve blood stasis mice arterial and venous blood Flow velocity effect. Conclusion: The main active ingredient of Huanghua Peacock grass promoting blood circulation is water extract. Its mechanism of action is to improve microcirculation and antithrombosis.