内源性阿片样肽是Hughes等人1975年发现并分离出来的,目前已在药理学、生物化学、生理学、解剖学、免疫学等许多方面取得很大进展。本文仅就内源性阿片样肽三种前体的结构及在中枢神经系统内的分布作一简介,并利用这些解剖研究,讨论有关阿片样肽生理作用的新假说,从而,为阿片样肽在中枢神经系统内的生理功能提供解剖依据。 Endogenous opioid peptide was discovered and isolated by Hughes et al in 1975 and has made great progress in many aspects such as pharmacology, biochemistry, physiology, anatomy and immunology. In this paper, we only give an introduction to the structure of endogenous opioid peptide precursors and their distribution in central nervous system, and use these anatomical studies to discuss a new hypothesis about the physiological effects of opioid peptides. Thus, The physiological function within the central nervous system provides an anatomic basis.