肺癌是严重威胁人类健康及生命的最常见的恶性肿瘤之一,肺癌发病率及病死率逐年提高,而非小细胞肺癌(NSCLC)的发病率占肺癌的70%～80%,其中约2/3的患者确诊时已失去手术机会,对这些患者主要采取以化疗为主的综合治疗。吉西他滨为阿糖胞苷的类似物,属于细胞周期特异性抗代谢类药 Lung cancer is one of the most common malignant tumors that seriously threaten human health and life. The incidence and mortality of lung cancer increase year by year, while the incidence of non-small cell lung cancer (NSCLC) accounts for 70% -80% of lung cancer, of which about 2 / 3 patients have lost the opportunity to confirm the diagnosis, mainly for these patients to chemotherapy-based comprehensive treatment. Gemcitabine is an analog of cytarabine and belongs to the cell cycle-specific anti-metabolite class