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目的探讨贫血在中国胃癌人群中的患病率和严重程度,分析影响胃癌患者贫血的独立因素。方法收集1 285例胃癌患者的临床资料,分析患者的贫血患病率、严重程度和影响其发生的独立因素。结果 1 285例胃癌患者中,63.2%的胃癌患者发生了不同程度的贫血,轻度、中度和重度贫血患者所占比例分别为48.6%、13.5%和1.1%。多因素回归分析结果显示,带瘤生存和既往接受过手术治疗是影响重度贫血发生的独立因素。手术切除范围、消化道重建方式、既往接受过铂类药物化疗、放射治疗、存在并发症和血小板计数<125×109/L均为影响D2根治术后患者发生中重度贫血的独立因素。结论胃癌人群中贫血发生率较高,临床治疗时应高度关注发生贫血的风险,积极采取预防和治疗措施以改善患者的生活质量。
Objective To investigate the prevalence and severity of anemia in Chinese gastric cancer patients and to analyze the independent factors affecting anemia in patients with gastric cancer. Methods The clinical data of 1 285 gastric cancer patients were collected to analyze the prevalence, severity and influencing factors of anemia. Results Among the 1 285 gastric cancer patients, 63.2% of patients with gastric cancer developed different degrees of anemia, with 48.6%, 13.5% and 1.1% of patients with mild, moderate, and severe anemia respectively. Multivariate regression analysis showed that tumor-bearing survival and previous surgical treatment were independent factors that affected the occurrence of severe anemia. The extent of resection, the way of reconstruction of the digestive tract, the previous received platinum chemotherapy, radiation therapy, the presence of complications and platelet count <125 × 109 / L are independent factors affecting the occurrence of moderate-severe anemia in patients after D2 radical operation. Conclusion The incidence of anemia in gastric cancer patients is high. The clinical treatment should be highly concerned with the risk of anemia. Active prevention and treatment measures should be taken to improve the quality of life of patients.