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目的:评价天钩降压胶囊对麻醉Beagle犬血压及血流动力学的影响。方法:天钩降压胶囊设置1.6,3.2,6.4 g.kg-13个剂量组(按生药计),以卡托普利为阳性对照药,0.5%CMC-Na为阴性对照药,十二指肠给药,观察麻醉犬血压及血流动力学的变化。结果:天钩降压胶囊中剂量组给药30 min后麻醉犬收缩压(SAP)明显降低,高剂量组给药后15 min SAP,舒张压(DAP)即明显降低,作用维持至给药后90 min。给予天钩降压胶囊高剂量能明显降低心脏做功(LVW)和总外周阻力(TPR)。天钩降压胶囊对其他血流动力学指标及心肌耗氧量无明显影响。结论:天钩降压胶囊具有明显降压作用,作用与降低总外周阻力有关,降压同时减少心脏做功,为进一步阐明天钩降压胶囊降血压机制提供参考。
Objective: To evaluate the effect of Tian hookjiangya capsule on blood pressure and hemodynamics in anesthetized Beagle dogs. Methods: Tian hook hypotensive capsules were set 1.6, 3.2, 6.4 g.kg-13 dose group (according to crude drug), captopril positive control drug, 0.5% CMC-Na negative control drug, Intestinal administration, observed anesthesia dogs blood pressure and hemodynamic changes. Results: The systolic blood pressure (SAP) in anesthetized dogs was significantly reduced 30 days after administration of Tian hookjiangya capsule, SAP and diastolic blood pressure (DAP) 15 minutes after administration were significantly decreased 90 min. High doses of Tian hooked hypotensive capsule can significantly reduce cardiac work (LVW) and total peripheral resistance (TPR). Tian hook hypotonic capsule on other hemodynamic parameters and myocardial oxygen consumption had no significant effect. Conclusion: Tian hook hypotensive capsule has a significant antihypertensive effect, and its role in reducing the total peripheral resistance, antihypertensive and reduce the work of the heart, to further clarify the antihypertensive mechanism of Tian hook hypotensive capsules provide a reference.