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目的:采用还原性谷胱甘肽(GSH)治疗高海拔地区酒精性肝炎患者,并对其血清肝纤维化相关指标进行检测,以观察GSH抵制肝纤维化作用。方法:随机将患者分为治疗组和对照组,每组28例,患者戒酒。治疗组:谷胱甘肽1.8g;对照组:派甘能60mL,一日一次,30天为一疗程。治疗前后空腹测血清透明质(HA)、血清层粘连蛋白(LN)、血清Ⅲ型胶原(PⅢP)、血清Ⅳ型型胶原(C-Ⅳ)。结果:通过对治疗组患者治疗前后肝纤维化四项指标含量变化测定比较发现,HA、PⅢP、C-Ⅳ,P值均<0.01,LNP值<0.05,具有明显差别。结论:缺氧状态下谷胱甘肽能迅速清除自由基,保护肝细胞膜,具有明显抑制肝纤维化作用,可广泛运用于高海拔酒精性肝炎的治疗。
Objective: To investigate the effect of GSH on liver fibrosis in patients with alcoholic hepatitis at high altitude by reducing glutathione (GSH). Methods: The patients were randomly divided into treatment group and control group, 28 cases in each group, patients were drinking alcohol. Treatment group: glutathione 1.8g; control group: sent to be able to 60mL, once a day, 30 days for a course of treatment. Fasting serum hyaluronic acid (HA), serum laminin (LN), serum type Ⅲ collagen (PⅢP) and serum type Ⅳ collagen (C-Ⅳ) were measured before and after treatment. Results: The changes of four indexes in liver fibrosis before and after treatment in the treatment group were significantly lower than those in the control group (P <0.01). CONCLUSION: Glutathione can rapidly scavenge free radicals and protect the liver cell membrane under hypoxic condition, with obvious inhibition of hepatic fibrosis. It can be widely used in the treatment of high altitude alcoholic hepatitis.