论文部分内容阅读
目的探讨新生儿呼吸机相关性肺炎(VAP)的发生率及其与通气时间的关系、病原学特点、防治措施。方法收集78例新生儿机械通气并发VAP进行分析。结果新生儿VAP的发生率57.7%,治愈率76.3%。45例VAP平均机械通气时间(125.2±11.0)h,33例未发生VAP平均机械通气时间为(75.3±23.2)h,两者比较差异有显著性意义(P<0.01)。2种细菌混合感染率(40.6%),气道分泌物培养致病菌培养以革兰阴性菌多见,耐药菌株较普遍。结论VAP是新生儿机械通气常见的并发症,其致病菌多为革兰阴性菌。混合感染及耐药是VAP病原学特点,应加强呼吸道无菌管理,其发生率与机械通气时间密切相关。
Objective To investigate the incidence of neonatal ventilator-associated pneumonia (VAP) and its relationship with ventilation time, etiological characteristics, prevention and treatment measures. Methods 78 neonates with mechanical ventilation were collected for VAP analysis. Results The incidence of neonatal VAP was 57.7%, the cure rate was 76.3%. 45 cases of VAP mean mechanical ventilation time (125.2 ± 11.0 h), 33 cases of VAP without mechanical ventilation (75.3 ± 23.2 h), the difference was significant (P <0.01). Mixed infection rate of two kinds of bacteria (40.6%), culture of airway secretions bacteria culture more common with gram-negative bacteria, resistant strains are more common. Conclusion VAP is a common complication of neonatal mechanical ventilation, the pathogens are mostly Gram-negative bacteria. Mixed infection and drug resistance are the etiological features of VAP. Aseptic management of respiratory tract should be strengthened, and the incidence is closely related to the time of mechanical ventilation.