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目的：探讨中性粘多糖（ Ｎ Ｍ ）对沙土鼠缺血再灌注后红细胞膜的保护作用。方法：采用沙土鼠脑缺血再灌注模型，观察 Ｎ Ｍ 对红细胞免疫粘附功能的影响，检测红细胞超氧化物歧化酶（ Ｒ Ｂ Ｃ Ｓ Ｏ Ｄ）和脂质过氧化物代谢产物丙二醛（ Ｒ Ｂ Ｃ Ｍ Ｄ Ａ）的含量，同时与淀粉对照组进行比较。结果： Ｎ Ｍ 可使沙土鼠再灌注时 Ｒ Ｂ Ｃ免疫粘附功能得到恢复； Ｒ Ｂ Ｃ Ｓ Ｏ Ｄ的含量轻度提高； Ｒ Ｂ Ｃ Ｍ Ｄ Ａ 含量明显降低。结论： Ｎ Ｍ 通过抗氧化作用对 Ｒ Ｂ Ｃ免疫粘附功能有调节作用，从而对沙土鼠缺血再灌注脑组织损伤时红细胞膜起到保护作用。
Objective: To investigate the protective effect of neutral mucopolysaccharide (N M) on erythrocyte membrane after ischemia-reperfusion in gerbils. Methods: The model of gerbil cerebral ischemia-reperfusion was used to observe the effect of N M on erythrocyte immune adherence function. The levels of erythrocyte superoxide dismutase (R B C S O D) and lipid peroxide metabolite Aldehyde (R B C M D A) content, while compared with the starch control group. RESULTS: N M could restore R B C immunoreactivity in reperfused gerbils, slightly increase R B C S O D, and significantly decrease R B C M D A in gerbils. CONCLUSION: N M can regulate the function of R B C immunoadhesion through anti-oxidation, and thus protect the erythrocyte membrane during cerebral ischemia-reperfusion injury in gerbils.