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目的观察兰索拉唑联合莫沙必利治疗胃食管反流病的临床效果以及不良反应。方法 88例胃食管反流病患者,将其按照不同的治疗方式分为观察组与对照组,每组44例。观察组给予兰索拉唑联合莫沙必利治疗,对照组给予兰索拉唑治疗。观察两组患者的临床治疗效果及不良反应发生情况。结果观察组患者的临床总有效率为97.73%,明显高于对照组的65.91%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为2.27%,明显低于对照组的22.73%,差异具有统计学意义(P<0.05)。结论胃食管反流病患者应用兰索拉唑联合莫沙必利治疗具有明显的效果,能有效改善患者的临床表现,并降低不良反应发生率,临床上值得推广及应用。
Objective To observe the clinical efficacy and adverse reactions of lansoprazole and mosapride in the treatment of gastroesophageal reflux disease. Methods 88 cases of gastroesophageal reflux disease patients were divided into observation group and control group according to different treatment methods, with 44 cases in each group. The observation group was treated with lansoprazole combined with mosapride and the control group with lansoprazole. The clinical efficacy and adverse reactions of the two groups were observed. Results The total clinical effective rate in observation group was 97.73%, which was significantly higher than that in control group (65.91%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 2.27%, which was significantly lower than that in the control group (22.73%), the difference was statistically significant (P <0.05). Conclusion Gastroesophageal reflux disease patients treated with lansoprazole combined with mosapride have obvious effects, which can effectively improve the clinical manifestations and reduce the incidence of adverse reactions, it is worth to promote and apply clinically.