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目的探讨一氧化氮等自由基与脑出血的关系。方法检测１３３例脑出血患者和１００例健康对照者血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）和过氧化脂质（Ｐ－ＬＰＯ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）、过氧化氢酶（Ｅ－ＣＡＴ）、谷胱甘肽过氧化物酶（Ｅ－ＧＳＨ－Ｐｘ）活性和过氧化脂质（Ｅ－ＬＰＯ）含量。结果与对照组比较，患者组Ｐ－ＮＯ、Ｐ－ＬＰＯ、Ｅ－ＬＰＯ均值显著升高（Ｐ＜０．００１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ、Ｅ－ＣＡＴ、Ｅ－ＧＳＨ－Ｐｘ均值显著降低（Ｐ＜０．００１）；逐步回归发现，患者病情（ＮＤＳ）与Ｐ－ＮＯ、Ｐ－ＶＣ、Ｅ－ＬＰＯ值相关最为密切，颅内血肿量与Ｐ－ＮＯ、Ｐ－ＶＥ、Ｅ－ＬＰＯ值相关最为密切。结论脑出血患者体内自由基反应病理性加剧，氧化抗氧化平衡严重失
Objective To investigate the relationship between free radicals such as nitric oxide and cerebral hemorrhage. Methods Plasma levels of plasma nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE), and β-carotene (P-CAR) were determined in 133 patients with cerebral hemorrhage and 100 healthy controls. (P-LPO) and the activity of E-SOD, E-CAT and E-GSH-Px And lipid peroxidation (E-LPO) content. Results Compared with the control group, the mean values of P-NO, P-LPO and E-LPO were significantly increased (P <0.001) (P <0.001). The results of stepwise regression showed that NDS was the most closely related to P-NO, P-VC and E-LPO. The intracranial hematoma was significantly correlated with E-GSH-Px P-NO, P-VE, E-LPO values most closely. Conclusion Cerebral hemorrhage in patients with pathological aggravating the radical reaction, a serious loss of balance of oxidation and antioxidation