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本文利用结扎犬冠脉左前降支造成急性心肌缺血模型，观察了冠脉内灌注强利尿心钠素０．６μｇ·ｋｇ￣（－１）·ｍｉｎ￣（－１），０．８μｇ·ｋｇ￣（－１）·ｍｉｎ￣（－１）及生理盐水对冠脉侧支循环及心肌氧代谢的影响。结果显示强利尿心钠素可使冠脉侧支返流血量分别增加１５２．７％和１２１．９％，心肌耗氧量分别自０．１９±０．０２，０．１８±０．０１增加至０．４２±０．０３和０．３８±０．０３ｍｌ·ｍｉｎ／１００ｇ心肌，供氧／耗氧比值分别增加１３．３％和６．０％。生理盐水对上述指标无明显作用。说明强利尿心钠素可显著改善冠脉侧支循环及心肌氧代谢异常。
In this study, acute left anterior descending coronary artery occlusion was used to induce acute myocardial ischemia in rats. Atrial natriuretic peptide (0.6μg · kg -1 · min -1), 0.8 μg · kg -1 ¯ (-1) · min ~ (-1) and saline on coronary collateral circulation and myocardial oxygen metabolism. The results showed that the strong diuresis atrial natriuretic can coronary blood flow increased by 152.7% and 121.9%, myocardial oxygen consumption from 0.19 ± 0.02,0.18 ± 0.01 Increased to 0.42 ± 0.03 and 0.38 ± 0.03ml · min / 100g myocardial, oxygen / oxygen ratio increased by 13.3% and 6.0%. Physiological saline no significant effect on the above indicators. The results showed that strong diuretic atrial natriuresis can significantly improve the coronary collateral circulation and myocardial oxygen metabolism.