氮质血症发生机理探讨一、氨氮的毒性作用:动物血液的氨含量若高至5毫克%,则立即死亡。1954年谢洛克(Sherlock)氏等从肝病人及瘘管手术病人血氨量的分析,也证明了氨中毒为引起神经症状的主要原因。谢洛克氏等发现肝病患者并发神经系症状时,其空腹周围血液中氨氮浓度高于正常的最高界限(每毫升1微克),脑脊液中的氨量也见增高。西葛密勒(Seegmiller)氏等在检验 Mechanism of azotemia to explore A, the toxic effects of ammonia nitrogen: animal blood ammonia content as high as 5 mg%, then immediately died. Analysis of blood ammonia levels in 1954 from patients with liver disease and fistula surgery, such as Sherlock’s, also proved that ammonia poisoning is the main cause of neurological symptoms. Sherlock et al found that patients with liver disease complicated by neurological symptoms, the fasting blood ammonia concentration above the normal upper limit of normal (1 microgram per milliliter), cerebrospinal fluid ammonia also increased. Seegmiller et al. Are testing