AIM:To study the eradication rate of Helicobacter pylori(Hp) in a group of type 2 diabetes and compared it with anage and sex matched non-diabeticgroup.METHODS:40 diabetic patients (21 females,19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females,20 males;54±9 years) were evaluated.Diabeticpatients with dyspeptic complaints were referred for uppergastrointestinal endoscopies;2 corpus and 2 antral gastricbiopsy specimens were performed on each patient.Patientswith positive Hp results on histopathological examinationcomprised the study group.Non-diabetic dyspeptic patientsseen at the Gastroenterology Outpatient Clinic and with thesame biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d),clarithromycin(500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given toboth groups for 10 days.Cure was defined as the absenceof Hp infection assessed by corpus and antrum biopsies incontrol upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial therapy.RESULTS:The eradication rate was 50% in the diabetic groupversus 85% in the non-diabetic control group (P<0.001).CONCLUSION:Type 2 diabetic patients showed a significantlylower eradication rate than controls which may be due tochanges in microvasculature of the stomach and to frequentantibiotic usage because of recurrent bacterial infections withthe development of resistant strains. AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with anage and sex matched non-diabetic group. METHODS: 40 diabetic patients (21 females, 19 males; 56 ± 7 years) and 40 non-diabetic dyspeptic patients (20 females, 20 males; 54 ± 9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy were were performed on each patient. Patients with positive Hp results on histopathological examination incorporated the study group. Non-diabetic dyspeptic patients sen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group. A triple therapy with amoxycillin (1 g bid), clarithromycin (500 mg bid) and omeprazole (20 mg bid) was given toboth groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies incontrol upper gastrointestinal endoscopies performed 6we Results of eks after completing the antimicrobial therapy .RESULTS: The eradication rate was 50% in the diabetic groupversus 85% in the non-diabetic control group (P <0.001) .CONCLUSION: Type 2 diabetic patients showed a significant low eradication rate than controls which may be due tochanges in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains.