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目的 :通过给急性心肌梗死患者应用吲达帕胺 (Ind) ,观察其在逆转急性心肌梗死左室重构中的作用。方法 :选择急性心肌梗死患者 116例 ,随机分为 Ind治疗组和对照组 (各 5 8例 )。用脉冲多普勒超声心动图测定等容舒张时间 (IVRT)、二尖瓣口血流频谱、肺静脉血流频谱和左室射血分数。结果 :Ind治疗组与对照组比较 :IVRT、EDT和 AR波时间明显缩短 ;E/ A比值、S/ D波幅比值、S/ D时间比值和 EF明显升高 ;AR/ A时间比值明显减小 ;AR波幅明显降低 ;L VDV和 L VSV明显缩小。结论 :Ind能显著改善急性心肌梗死患者的左室收缩及舒张功能 ,Ind能逆转急性心肌梗死后左室重构
OBJECTIVE: To observe the effect of indapamide (Ind) on left ventricular remodeling in acute myocardial infarction (AMI) patients by applying it to patients with acute myocardial infarction. Methods: One hundred and sixty-six patients with acute myocardial infarction (AMI) were randomly divided into Ind and control groups (58 and 58 respectively). Pulse-Doppler echocardiography was used to determine isovolumetric relaxation time (IVRT), mitral valve flow spectrum, pulmonary venous flow and left ventricular ejection fraction. Results: Compared with the control group, the time of IVRT, EDT and AR wave were shortened significantly; the ratio of E / A, S / D amplitude ratio, S / D ratio and EF significantly increased; ; AR amplitude decreased significantly; LVDV and L VSV significantly reduced. Conclusion: Ind can significantly improve left ventricular systolic and diastolic function in patients with acute myocardial infarction. Ind can reverse left ventricular remodeling after acute myocardial infarction