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将本部发现的一只无毛KM小鼠进行回交和自交后,自1995年2月起采取全同胞兄妹交配的方法,培育至今已达F18.代间隔平均为71.5D(55~116D).以近交F18与DBA/2交配进行毛色基因测试,其杂交1代毛色一致,提示F18无毛小鼠已达到较高的基因纯合度.该无毛小鼠自4周龄起全身开始脱毛,至5周龄全身基本无毛,6周龄后又长出稀短的毛.该鼠已经剖宫取胎净化为清洁级.“,”The hairless mutant mouse was found in KM closed colony.The “hairless” gene was retained by backcrossing and brother × sister mating system.The inbree ding had progressed to the 18th generation since February 1995.The average gener ation interval was 71.5 days (55116 days).The result of coat color t est crossing of the F18 with DBA/2 showed that the color genes in F18 were homog enous.The hairless mice start to shed at the age of 4 weeks and lose almost all hairs at the age of 5 weeks.The sparse and short...