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目的:分析讨论甘精胰岛素与地特胰岛素治疗老年2型糖尿病患者的临床疗效。方法:随机抽取我院收治的80例老年2型糖尿病患者,将他们随机的分成研究组和对照组。研究组患者在常规化的降糖方案治疗基础上,给予患者睡前皮下注射地特胰岛素治疗,对照组患者同样在常规化的降糖方案治疗基础上,给予患者睡前皮下注射甘精胰岛素治疗,比较两组患者治疗前后血糖改善情况、Hb A1c、FBG、2h-BG以及体重增加情况。结果:两组患者治疗后的FBG、2h-BG和治疗前相比均有明显改善,但组间比较无统计学意义(p>0.05),研究组患者在控制体重增加以及低血糖发生概率方面显著优于对照组,差异具有统计学意义(P<0.05)。结论:治疗老年2型糖尿病时,甘精胰岛素与地特胰岛素在安全性和有效性方面相似,但是地特胰岛素能够显著改善患者体重增加状况以及低血糖发生率,值得在临床上推广应用。
Objective: To analyze and discuss the clinical efficacy of insulin glargine and insulin detemir in the treatment of elderly type 2 diabetes patients. Methods: A total of 80 elderly patients with type 2 diabetes mellitus admitted to our hospital were randomly divided into study group and control group. Patients in the study group were treated with insulin dextrose injected subcutaneously before bedtime on the basis of routine treatment of hypoglycemic regimen. Patients in the control group were also treated with insulin glargine subcutaneously before bedtime on the basis of routine hypoglycemic regimen treatment The improvement of blood glucose, Hb A1c, FBG, 2h-BG and weight gain were compared between the two groups before and after treatment. Results: FBG and 2h-BG after treatment in both groups were significantly improved compared with those before treatment, but there was no significant difference between the two groups (p> 0.05). The study group’s effect on weight gain and the incidence of hypoglycemia The difference was statistically significant (P <0.05). CONCLUSIONS: Glargine and insulin detemir are similar in safety and efficacy for the treatment of type 2 diabetes in the elderly, but detemir can significantly improve the patient’s weight gain and the incidence of hypoglycaemia and is worthy of clinical application.