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目的:检测p53和survivin蛋白在食管癌组织中的表达,探讨其意义。方法:应用免疫组织化学法检测食管癌及正常食管粘膜组织中p53、survivin蛋白的表达情况。结果:p53、survivin在食管癌组织中的表达量均高于正常食管粘膜组织(P<0.05),p53、survivin高表达与食管癌淋巴结转移状况差异有关(P<0.05),与性别、年龄、肿瘤长度、浸润深度、分化程度无关(P>0.05)。p53和survivin蛋白在食管癌中表达呈明显正相关性(R=0.218,P<0.05)。结论:p53、survivin在食管癌中高表达(82.1%&71.9%),二者在食管癌的淋巴结转移中发挥重要作用,并具有协同作用。
Objective: To detect the expression of p53 and survivin protein in esophageal carcinoma and to explore its significance. Methods: Immunohistochemistry was used to detect the expression of p53 and survivin protein in esophageal cancer and normal esophageal mucosa. Results: The expression of p53 and survivin in esophageal carcinoma was significantly higher than that in normal esophageal mucosa (P <0.05). The high expression of p53 and survivin was associated with lymph node metastasis of esophageal cancer (P <0.05) Tumor length, depth of invasion, differentiation degree (P> 0.05). p53 and survivin protein expression in esophageal cancer was positively correlated (R = 0.218, P <0.05). Conclusions: The expression of p53 and survivin in esophageal cancer is high (82.1% & 71.9%), both of which play an important role in the lymph node metastasis of esophageal cancer and have a synergistic effect.