近年来,通过甘氨酸酯 Sohiff 碱衍生物的烷基化反应,合成较高级的α-氨基酸的研究工作引人注目。其中相转移催化烷基化反应具有反应条件温和、选择性好、操作简便和费用低廉的特点.O’Donnell 等报道,醛亚胺 Sohiff 碱1的酸性低、不稳定,难于作为烷基化反应的中间体,而酸性较高的酮亚胺 Sohiff 碱2较为稳定,可作为相转移催化烷基化反应的底 In recent years, the research on the synthesis of higher-level α-amino acids has drawn much attention through the alkylation of glycine ester Sohiff base derivatives. Among them, phase transfer catalysis alkylation has the advantages of mild reaction conditions, good selectivity, easy operation and low cost.O’Donnell et al. Reported that the aldimine Sohiff base 1 has low acidity and is unstable and difficult to be used as an alkylation reaction , While the more acidic ketimine base 2 is more stable and can be used as the base of the phase transfer catalysis alkylation