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用ＥＬＩＳＡ法测定了１２７例类风湿性关节炎（ＲＡ）四种证型的患者和３２例正常人血清可溶性白细胞介素Ⅱ受体（ｓＩＬ２Ｒ）以及其它有关指标。结果四种证型（寒湿阻络证、湿热阻络证、气阴两虚证、肝肾两虚证）患者ｓＩＬ２Ｒ的水平均显著升高，治疗后又明显地下降。肝肾两虚证ｓＩＬ２Ｒ的水平高于其它三种证型；四证共同主要症状与ｓＩＬ２Ｒ之间未见特异性。ｓＩＬ２Ｒ水平升高，ＥＳＲ的水平也明显升高，经治疗后又同步下降。四证治疗后ｓＩＬ２Ｒ水平的下降可能是药物抑制ＴＨ细胞的结果，也可能是直接抑制ｓＩＬ２Ｒ基因表达的结果。结果提示，ＲＡ患者血清ｓＩＬ２Ｒ的水平是体内免疫功能状态的反映，以上四种证型可能存在着四种不同的免疫功能状态。单一的ｓＩＬ２Ｒ不能反映证型的特点，不能作为辨别各证型的依据，但却是用来监控ＲＡ活动的重要指标，也是用于评价药物疗效很好的指标。
Serum soluble interleukin-2 receptor (sIL-2R) and other related indicators were determined in 127 patients with rheumatoid arthritis (RA) syndromes and 32 normal controls by ELISA. Results The levels of sIL2R in four syndromes (cold and dampness resistance syndrome, damp and heat resistance syndrome, qi and yin deficiency syndrome, liver and kidney deficiency syndrome) were significantly increased, and then decreased significantly after treatment. Liver and kidney deficiency sIL 2R levels higher than the other three syndromes; four syndromes common main symptoms and sIL 2R no specific. sIL 2R levels increased, the level of ESR also significantly increased after treatment decreased simultaneously. The decline of sIL 2R levels after treatment may be the result of drugs inhibiting TH cells, and may also directly inhibit the expression of sIL 2R gene. The results suggest that RA serum sIL 2R levels reflect the status of immune function in vivo, the above four syndromes may exist in four different immune function status. A single sIL 2R can not reflect the characteristics of the syndrome, can not be used as a basis for the identification of each syndrome, but it is used to monitor RA activity of the important indicators, but also for evaluation of good drug efficacy indicators.