论文部分内容阅读
目的探讨老年代谢综合征与瘦素及IGF水平的相关性。方法入选2009年7月~2011年在某院就诊的老年代谢综合征患者79例,入选同期在该院进行健康查体人群76例作为对照组,比较两组人群瘦素及IGF水平,并分析其与代谢综合征各组分的相关性。结果对照组人群血清瘦素水平显著低于代谢综合征组患者,而IGF水平则显著升高,差异均具有统计学意义(P﹤0.05);分析显示,瘦素水平与SBP、BMI、WC存在显著正相关,而与HDL-C存在明显负相关;胰岛素样生长因子与BMI、TG存在明显负相关,r=-0.312,-0.216,P﹤0.05。结论老年代谢综合征患者存在明显的胰岛素抵抗现象,瘦素及IGF在代谢综合征的发生中都发挥了非常重要的作用。
Objective To investigate the correlation between metabolic syndrome and leptin and IGF levels in elderly patients. Methods A total of 79 elder patients with metabolic syndrome who were treated in a hospital from July 2009 to 2011 were enrolled in this study. 76 healthy volunteers were enrolled as control group. The levels of leptin and IGF were compared between the two groups It correlates with the components of the metabolic syndrome. Results The level of serum leptin in control group was significantly lower than that in patients with metabolic syndrome, while the level of IGF was significantly increased (P <0.05). Analysis showed that there was significant difference between leptin and SBP, BMI and WC But negatively correlated with HDL-C. There was a significant negative correlation between insulin-like growth factor and BMI and TG (r = -0.312, -0.216, P <0.05). Conclusion There are obvious insulin resistance in elderly patients with metabolic syndrome. Leptin and IGF play a very important role in the development of metabolic syndrome.