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纳米技术和纳米医学的研究在生物医学、疾病诊断和治疗方面显示出了巨大的应用潜力.有机荧光分子基检测技术已被广泛的用作造影和信号转换的工具用以测定痕量的分析物.然而,有机荧光分子基团的降解、光漂白作用使得其荧光的稳定性受到影响,从而限制了它们在复杂的生理环境中的应用.无机纳米粒子因其形状、尺寸和组成的不同而具有独特且稳定的光、电、磁及催化性能,可用作新型的生物纳米造影材料,能很好的解决造影检测技术所面临的难题.并且,纳米造影材料的表面修饰则可以提高它们的在生理条件下的稳定性和靶向生物活性分子的能力.
Research in nanotechnology and nanomedicine has shown tremendous potential in biomedicine, disease diagnosis and treatment.Organofluorescence molecular-based detection has been widely used as a tool for imaging and signal transduction to determine trace amounts of analytes However, the degradation and photo-bleaching of organic fluorescent molecules affect the stability of their fluorescence, which limits their application in complex physiological environment.The inorganic nanoparticles have different shapes, sizes and compositions Unique and stable optical, electrical, magnetic and catalytic properties, can be used as a new type of bio-nano-imaging materials, can solve the problem of contrast detection technology and nano-imaging materials can improve their surface modification Physiological stability and ability to target bioactive molecules.