论文部分内容阅读
目的探讨血清中转化生长因子β1(TGF-β1)在Graves病复发中的作用。方法收集在本院门诊就诊的Gra-ves病患者60例,分为Graves病初诊组20例,Graves病治疗3个月组20例,Graves病复发组20例,健康对照组20例来自本院健康查体人群。应用ELISA方法测定各组血清TGF-β1及促甲状腺激素受体抗体(TRAb)的水平,采用电化学发光方法测定各组血清甲状腺激素水平及甲状腺过氧化酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)的水平。结果Graves病初诊组和复发组血清TGF-β1水平均较健康对照组显著增高(P<0.01),治疗3个月组血清TGF-β1水平较初诊组显著降低(P<0.01),复发组血清TGF-β1水平低于初诊组(P<0.01),但明显高于治疗3个月组(P<0.01)。结论血清TGF-β1可能参与了Graves病的发生及复发过程。
Objective To investigate the role of serum transforming growth factor-β1 (TGF-β1) in the relapse of Graves disease. Methods Sixty Graves’ disease patients were collected in this outpatient clinic. They were divided into 20 cases of Graves disease, 20 cases of Graves disease, 3 cases of Graves disease, 20 cases of Graves disease relapse and 20 cases of healthy control. Health check the crowd. Serum levels of TGF-β1 and thyrotropin receptor antibody (TRAb) were measured by ELISA. Serum levels of thyroid hormone and thyroid hormone (TPOAb) and thyroglobulin antibody TGAb) levels. Results Serum levels of TGF-β1 in the newly diagnosed group and relapsed group were significantly higher than those in the healthy control group (P <0.01), and the levels of TGF-β1 in the three-month treatment group were significantly lower than those in the newly diagnosed group (P <0.01) TGF-β1 level was lower than the newly diagnosed group (P <0.01), but significantly higher than the 3-month treatment group (P <0.01). Conclusion Serum TGF-β1 may be involved in the occurrence and relapse of Graves’ disease.