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本实验采用敏感性较高的ＰＡＰ法检测了ＨＳＶ－２诱发的移植性小鼠宫颈癌和增生组织中的ＨＳＶ－２抗原。结果３０例ＨＳＶ－２诱发的增生或癌组织中有２４例阳性，阳性率达８０％。１４例经ＨＳＶ－２处理的非增生、非癌性宫颈组织中４例阳性，阳性率为２８．５７％。两组阳性率有显著性差异（Ｐ＜０．０１）。本实验在改良了传统的诱癌模型情况下，检测了ＨＳＶ－２抗原的表达并进一步确立了ＨＳＶ－２在实验性小鼠宫颈癌发生中的作用。
In this study, HSV-2 induced HSV-2 induced HSV-2 antigen in cervical cancer and proliferative tissues was detected by PAP with high sensitivity. Results Of the 30 cases of HSV-2 induced hyperplasia or carcinoma, 24 cases were positive and the positive rate was 80%. Four of the 14 non-proliferative and non-cancer cervical tissues treated with HSV-2 were positive, with a positive rate of 28.57%. There was a significant difference in the positive rate between the two groups (P<0.01). This experiment has improved the traditional cancer-inducing model, detected the expression of HSV-2 antigen and further established the role of HSV-2 in the development of experimental mouse cervical cancer.