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目的:利用泻下加劳倦过度方式结合皮下接种H-22肝癌细胞的模式造成脾虚型荷瘤小鼠模型。方法:16只昆明小鼠随机分为对照组和模型组,每组8只,10天后取食量、体重、肛温、腹泻、肛门污秽、拉尾排便次数、悬空拉尾抵抗时间及一般状况(拱背、毛色枯槁及脱毛、倦卧嗜睡等),作小鼠脾虚征象详情记录。取血测定血清D-木糖醇、血清胃泌素、处死剖取胸腺、脾脏称重,计算胸腺指数和脾脏指数,评价模型的建立和病理生理特点。结果:造模后,造模小鼠腋下均长出肿瘤结节,并且出现明显食少、稀便、肛门污秽、神软萎靡、喜聚堆倦伏、毛色枯槁、拱背竖毛、活动缓慢、反应迟钝等脾虚证状,以第6天最显著。结论:泻下加劳倦过度方式结合皮下接种H-22肝癌细胞的模式在小鼠体内可以成功建立病证结合的脾虚证荷瘤模型。
OBJECTIVE: To establish a model of tumor-bearing mice with spleen-deficiency syndrome by means of diarrhea and fatigue over-combined with subcutaneous H-22 hepatoma cells. Methods: Sixteen Kunming mice were randomly divided into control group and model group, with 8 rats in each group. The food intake, body weight, rectal temperature, diarrhea, anal contamination, the number of lassitude defecation, (Arch back, brown hair and hair loss, drowsiness, drowsiness, etc.) for the details of the spleen symptoms record. Blood samples were collected for determination of serum D-xylitol and serum gastrin. Thymus and spleen were sacrificed and sacrificed. The thymus index and spleen index were calculated. The establishment of the model and pathophysiological characteristics were also evaluated. Results: After the model was established, all the mice in the model had tumor nodules, and there were obvious symptoms such as less food, loose stools, anal contamination, apathetic depression, tired and tired, plump hair, Slow, unresponsive and other spleen-like syndrome, the most significant on the 6th day. Conclusion: The model of spleen-deficiency tumor-bearing can be successfully established in mice by combination of the model of Hyperoxia and Hyperaemia combined with subcutaneous inoculation of H-22 hepatoma cells.