对Ｂ超、ＣＴ检查发现的肝脏实质性占位病变４８例患者进行血、胆汁ＡＦＰ联合检测及肝穿活检或手术病检进行诊断对照。结果，血、胆汁ＡＦＰ均阴性的６例，排除了肝细胞癌（ＨＣＣ）。４２例血、胆汁ＡＦＰ至少一项阳性者均为ＨＣＣ。提示ＨＣＣ患者其ＡＦＰ除入血循环外，还可随胆汁排泄。血、胆汁ＡＦＰ两项阳性的ＨＣＣ，占２８．６％；血ＡＦＰ阳性胆汁ＡＦＰ阴性者占４５．２％；血ＡＦＰ阴性胆汁ＡＦＰ阳性者占２６．２％。而血及胆汁ＡＦＰ联检则ＨＣＣ的诊断阳性率为１００％。 48 patients with solid lesions of the liver detected by ultrasound and CT examinations were examined for blood and bile AFP joint detection, liver biopsy or surgical examination. As a result, six patients with negative blood and bile AFPs were excluded from hepatocellular carcinoma (HCC). 42 cases of blood, bile AFP at least one positive is HCC. It is suggested that the AFP of HCC patients can be excreted with bile in addition to blood circulation. Blood, bile AFP two positive HCC, accounting for 28.6%; blood AFP positive bile AFP negative accounted for 45.2%; blood AFP negative bile AFP positive accounted for 26.2%. The combined positive rate of HCC in blood and bile AFP was 100%.