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目的探讨血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)和半胱氨酸蛋白酶抑制剂C(Cystatin C)水平与冠心病(CHD)的相关性。方法选择经冠状动脉造影检查的患者共137例,分为对照组50例、稳定型心绞痛组(SAP)45例和急性冠脉综合征组(ACS)42例。采用速率散射光比浊法测定血清hs-CRP、Cystatin C,荧光偏振免疫发光技术(FPIA)检测血清Hcy。结果CHD患者血清hs-CRP、Hcy和Cystatin C水平明显高于对照组,且二者血清水平均与病情严重程度相关;CHD组血清Hcy与hs-CRP、Cystatin C呈正相关(r=0.405、0.339,P<0.05),Cystatin C与hs-CRP无相关。结论hs-CRP、Hcy和Cystatin C与冠心病的发生、发展有重要关系;CHD组Hcy与hs-CRP、Cys-tatin C呈正相关。
Objective To investigate the relationship between serum hs-CRP, homocysteine (Hcy) and Cystatin C levels and coronary heart disease (CHD). Methods A total of 137 patients undergoing coronary angiography were selected and divided into control group (50 cases), stable angina pectoris group (SAP) and acute coronary syndrome group (ACS), 42 cases. Serum hs-CRP, Cystatin C were determined by rate-scattering nephelometry. Serum Hcy was detected by fluorescence polarization immunoassay (FPIA). Results Serum levels of hs-CRP, Hcy and Cystatin C in patients with CHD were significantly higher than those in controls, and the serum levels of both were correlated with the severity of the disease. There was a positive correlation between serum Hcy and hs-CRP and Cystatin C in CHD patients (r = 0.405,0.339 , P <0.05), Cystatin C had no correlation with hs-CRP. Conclusions There is a significant relationship between hs-CRP, Hcy and Cystatin C in the pathogenesis and development of coronary heart disease. Hcy in CHD group is positively correlated with hs-CRP and Cys-tatin C.